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Orlistat vs. sibutramine for weight loss [see WARNINGS AND PRECAUTIONS]. The effectiveness of dieting on weight change has yet to be demonstrated in randomized controlled trials, but several small randomized controlled trials have found it to be effective in terms of weight loss among overweight/obese individuals (i.e., ≥40% weight loss) (2–5). Therefore, dieting has a place for certain persons with obesity who are unable or unwilling to achieve and maintain a BMI <30 or <25, and who are unable to lose weight in spite of engaging energy restriction and increasing physical activity. Dieting should be avoided with severe or stable medical conditions, as it may be associated with a range of unwanted side effects, including low blood pressure, heart disease, abnormal count, liver damage, and depression. Weight-loss pharmacological agents Pharmacological agents that can be used as a weight-loss intervention include the following: Bariatric surgery (surgical excision of the belly and/or retention some abdominal muscle or fat) is the most commonly prescribed for weight loss (6). However, during or following bariatric surgery does not always reduce risk factors associated with obesity. Bariatric surgery requires long-term follow-up and monitoring. Weight-loss surgery may also not result in long-term weight-loss if the surgeon does not consider other lifestyle interventions that are more successful in lowering weight (7). The results of a meta-analysis that evaluated weight-loss surgery, including gastric bypass showed that the reduction of body weight did not always follow surgery (8). Gastric bypass is associated with a reduction in body weight and is the most commonly used surgical treatment for individuals who have an average or greater BMI of 30 kg/m2 or greater. Gastric bypass is generally associated with fewer adverse effects than bariatric surgery, but orlistat weight loss drug the risk of some chronic conditions is elevated among patients who undergo gastric bypass (e.g., diabetes), including type 2 diabetes and cardiovascular disease (1). Patients who are unable Buy finpecia in the uk to achieve and maintain a BMI <30 or <25 following a bariatric surgery should be monitored to ensure their adherence treatment. In general, gastric bypass is not recommended for obese patients (1,9,10,11,12). Surgical weight loss in obesity is associated with weight loss longer duration, greater improvement in waist circumference the 6 months following surgery, and reduced mortality (13).

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